Table 3. Univariate and multivariate analysis: CT-derived parameters and clinical characteristics predicting MACE.
| Variables | Univariate analysis | Multivariate analysis* | |||||
|---|---|---|---|---|---|---|---|
| HR | 95% CI | P value | HR | 95% CI | P value | ||
| CACS ≥519.95 | 11.109 | 3.535–34.916 | <0.001 | 3.759 | 1.146–12.329 | 0.029 | |
| CAD-RADS ≥3 | 7.094 | 1.591–31.619 | 0.010 | ||||
| HRP | 2.955 | 1.005–8.688 | 0.049 | ||||
| MBFischemic ≤119.5 mL/100 mL/min | 41.485 | 5.434–316.683 | <0.001 | 23.382 | 2.859–191.231 | 0.003 | |
| MBFratio ≤0.82 | 21.550 | 4.819–96.377 | <0.001 | ||||
| CT-FFR ≤0.8 | 6.827 | 1.922–24.253 | 0.003 | ||||
| Age ≥71 years | 4.855 | 1.545–15.260 | 0.007 | ||||
| Male | 0.655 | 0.233–1.844 | 0.424 | ||||
| Diabetes mellitus | 2.952 | 1.070–8.144 | 0.037 | ||||
| Hypertension | 35.747 | 0.343–3,722.158 | 0.131 | ||||
| Dyslipidemia | 0.735 | 0.261–2.066 | 0.559 | ||||
| Current smoking | 0.773 | 0.174–3.443 | 0.736 | ||||
*, data for variables not included in the equation using the “forward” method were not provided. CACS, coronary artery calcium score; CAD-RADS, Coronary Artery Disease - Reporting and Data System; CI, confidence interval; CT, computed tomography; CT-FFR, computed tomography fractional low reserve; HR, hazard ratio; IQR, interquartile range; MACE, major adverse cardiac event; MBF, myocardial blood flow; SD, standard deviation.