Table 1. Pediatric patients with PVOD reported in the literature.
Author | Age at diagnosis | History, risk factors | Mode of diagnosis |
---|---|---|---|
Allewelt (16) | 6 months | Allogeneic hematopoietic stem cell transplantation | Unknown |
Bürki (2) | 15 years | Unknown | Autopsy |
Cohn (17) | 6 years | Unknown | Histology (open lung biopsy) |
Davies (18) | 13 years | Unknown, possibly heritable (sibling) | Histology |
14 years | Unknown, possibly heritable (sibling) | Histology | |
Davis (19) | 17 years | Unknown | Computed tomography and histology |
Day (20) | 6 years | Heritable | Autopsy |
8 years | Juvenile idiopathic arthritis | Computed tomography | |
9 years | Heritable | Autopsy | |
De Vries (21) | 12 years | Unknown | Histology (open lung biopsy) |
Gupta (22) | 12 years | Unknown | Computed tomography |
Hackman (23) | 4 years | Acute lymphoblastic leukemia (chemotherapy: vincristine, prednisone, asparaginase, daunomycin and methotrexate), bone marrow transplantation | Histology (open lung biopsy) |
4 years | Acute lymphoblastic leukemia (chemotherapy: vincristine, prednisone, asparaginase and methotrexate), bone marrow transplantation | Clinically | |
Heath (24) | 5 years | Repeated bronchitis and chest infection | Histology |
Holcomb (13) | 9 years | Unknown | Computed tomography |
Hussein (25) | 12 years | Antiphospholipid syndrome | Unknown |
Isshiki (26) | 5 years | Neuroblastoma. Stem cell transplantation | Computed tomography |
Justo (27) | 7 years | Unknown | Histology (open lung biopsy) |
17 years | Unknown | Histology (open lung biopsy) | |
11 years | Dysmorphic features, developmental delay, coarctation of the aorta | Histology (open lung biopsy) | |
5 months | Unknown | Autopsy | |
Kano (28) | 11 years | Unknown | Autopsy |
Kawashima (29) | 7 months | Acute lymphoblastic leukemia (chemotherapy: busulfan, cyclophosphamide, etoposide), stem cell cord blood | Computed tomography |
4 years | Acute lymphoblastic leukemia (chemotherapy: cyclophosphamide, etoposide, carmustine), stem cell transplantation | Computed tomography | |
2 years | Neuroblastoma (chemotherapy: carboplatin, etoposide, melphalan), stem cell transplantation | Computed tomography | |
Liang (30) | 5 years | Congenital heart disease (tetralogy of Fallot) | Cardiac catheterization |
Liebow (31) | 5 patients <16 years | Unknown | – |
Lombard (32) | 17 years | Malignant glioma (chemotherapy: carmustin) | Histology (open lung biopsy) and autopsy |
Matsumoto (33) | 5 years | Unknown | Histology (open lung biopsy) |
Miyata (34) | 5 years | Burkitt lymphoma (chemotherapy: cyclophosphamide, vincristine, cytosine, arabinoside, epirubicin, etoposide, methotrexate) | Computed tomography and histology |
Montani (35) | 17 years | Heritable | Computed tomography |
16 years | Heritable | Computed tomography | |
15 years | Heritable | Computed tomography | |
12 years | Heritable | Computed tomography | |
10 years | Heritable | Computed tomography | |
7 years | Heritable | Computed tomography | |
Neonatal | Heritable | Computed tomography | |
Moreno-Galdó (36) | 0.3 years | Unknown | Computed tomography |
Muneuchi (37) | 4 months | Trisomy 21 | Autopsy |
Nohe (38) | Unknown | Unknown | Histology |
Ogawa (39) | 16 years | Unknown | Histology |
Rosenthal (40) | 13 years | Unknown | Autopsy |
Shrivastava (41) | 7 years | Left pulmonary venous atresia, pneumonectomy | Autopsy |
Swensen (42) | 5 years | Unknown | Computed tomography |
Takahashi (43) | 6 years | Unknown | Computed tomography |
Tenorio (44) | 15 years | Heritable | Histologically proven |
Trobaugh-Lotrario (45) | 9 months | Neuroblastoma (chemotherapy: cyclophosphamide) | Autopsy |
4 years | Acute lymphoblastic leukemia | Histology (open lung biopsy) | |
4 years | Acute lymphoblastic leukemia | Clinically | |
Urisman (46) | 14 years | Oral contraceptives | Histology |
18 years | Oral contraceptives, systemic lupus erythematosus and antiphospholipid antibody | Histology | |
Voordes (47) | 2 months | None, sibling affected | Autopsy |
Voordes (47) | 2 months | None, sibling affected | Autopsy |
Weisser (10) | 15 years | Unknown (pertussis at the age of 6 months, and later rubella, varicella, and mumps) | Autopsy |
Woerner (12) | 9 children 8–16 years | Bronchial asthma, allergic alveolitis, bilateral renal dysplasia, ichthyosis, velopharyngeal incompetence, congenital heart disease, Myhre syndrome, long-term immunosuppressive treatment (tacrolimus and tacrolimus, azathioprine, prednisone) after (nonlung) solid organ transplantation | Histology (open lung biopsy), autopsy |
Yang (48) | 6 years | None | Autopsy |
PVOD, pulmonary veno-occlusive disease.