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. 2021 Aug;11(4):1070–1079. doi: 10.21037/cdt-20-320

Table 1. Pediatric patients with PVOD reported in the literature.

Author Age at diagnosis History, risk factors Mode of diagnosis
Allewelt (16) 6 months Allogeneic hematopoietic stem cell transplantation Unknown
Bürki (2) 15 years Unknown Autopsy
Cohn (17) 6 years Unknown Histology (open lung biopsy)
Davies (18) 13 years Unknown, possibly heritable (sibling) Histology
14 years Unknown, possibly heritable (sibling) Histology
Davis (19) 17 years Unknown Computed tomography and histology
Day (20) 6 years Heritable Autopsy
8 years Juvenile idiopathic arthritis Computed tomography
9 years Heritable Autopsy
De Vries (21) 12 years Unknown Histology (open lung biopsy)
Gupta (22) 12 years Unknown Computed tomography
Hackman (23) 4 years Acute lymphoblastic leukemia (chemotherapy: vincristine, prednisone, asparaginase, daunomycin and methotrexate), bone marrow transplantation Histology (open lung biopsy)
4 years Acute lymphoblastic leukemia (chemotherapy: vincristine, prednisone, asparaginase and methotrexate), bone marrow transplantation Clinically
Heath (24) 5 years Repeated bronchitis and chest infection Histology
Holcomb (13) 9 years Unknown Computed tomography
Hussein (25) 12 years Antiphospholipid syndrome Unknown
Isshiki (26) 5 years Neuroblastoma. Stem cell transplantation Computed tomography
Justo (27) 7 years Unknown Histology (open lung biopsy)
17 years Unknown Histology (open lung biopsy)
11 years Dysmorphic features, developmental delay, coarctation of the aorta Histology (open lung biopsy)
5 months Unknown Autopsy
Kano (28) 11 years Unknown Autopsy
Kawashima (29) 7 months Acute lymphoblastic leukemia (chemotherapy: busulfan, cyclophosphamide, etoposide), stem cell cord blood Computed tomography
4 years Acute lymphoblastic leukemia (chemotherapy: cyclophosphamide, etoposide, carmustine), stem cell transplantation Computed tomography
2 years Neuroblastoma (chemotherapy: carboplatin, etoposide, melphalan), stem cell transplantation Computed tomography
Liang (30) 5 years Congenital heart disease (tetralogy of Fallot) Cardiac catheterization
Liebow (31) 5 patients <16 years Unknown
Lombard (32) 17 years Malignant glioma (chemotherapy: carmustin) Histology (open lung biopsy) and autopsy
Matsumoto (33) 5 years Unknown Histology (open lung biopsy)
Miyata (34) 5 years Burkitt lymphoma (chemotherapy: cyclophosphamide, vincristine, cytosine, arabinoside, epirubicin, etoposide, methotrexate) Computed tomography and histology
Montani (35) 17 years Heritable Computed tomography
16 years Heritable Computed tomography
15 years Heritable Computed tomography
12 years Heritable Computed tomography
10 years Heritable Computed tomography
7 years Heritable Computed tomography
Neonatal Heritable Computed tomography
Moreno-Galdó (36) 0.3 years Unknown Computed tomography
Muneuchi (37) 4 months Trisomy 21 Autopsy
Nohe (38) Unknown Unknown Histology
Ogawa (39) 16 years Unknown Histology
Rosenthal (40) 13 years Unknown Autopsy
Shrivastava (41) 7 years Left pulmonary venous atresia, pneumonectomy Autopsy
Swensen (42) 5 years Unknown Computed tomography
Takahashi (43) 6 years Unknown Computed tomography
Tenorio (44) 15 years Heritable Histologically proven
Trobaugh-Lotrario (45) 9 months Neuroblastoma (chemotherapy: cyclophosphamide) Autopsy
4 years Acute lymphoblastic leukemia Histology (open lung biopsy)
4 years Acute lymphoblastic leukemia Clinically
Urisman (46) 14 years Oral contraceptives Histology
18 years Oral contraceptives, systemic lupus erythematosus and antiphospholipid antibody Histology
Voordes (47) 2 months None, sibling affected Autopsy
Voordes (47) 2 months None, sibling affected Autopsy
Weisser (10) 15 years Unknown (pertussis at the age of 6 months, and later rubella, varicella, and mumps) Autopsy
Woerner (12) 9 children 8–16 years Bronchial asthma, allergic alveolitis, bilateral renal dysplasia, ichthyosis, velopharyngeal incompetence, congenital heart disease, Myhre syndrome, long-term immunosuppressive treatment (tacrolimus and tacrolimus, azathioprine, prednisone) after (nonlung) solid organ transplantation Histology (open lung biopsy), autopsy
Yang (48) 6 years None Autopsy

PVOD, pulmonary veno-occlusive disease.