FIGURE 2.

Main processing steps of the longitudinal pipeline of icobrain (v5.0.1) for computing the percent brain volume change (PBVC). The PBVC_+scaling results from the combination of the estimated PBVC, from the volume at time point 1 (TM1) and then from the volume at time point 2 (TM2), by the modulation of the scaling factor extracted from the affine registration of the head images and the Jacobian determinant of the deformation field obtained from the nonrigid registration of the brain images