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. Author manuscript; available in PMC: 2022 Sep 1.
Published in final edited form as: Neuropharmacology. 2021 May 26;195:108623. doi: 10.1016/j.neuropharm.2021.108623

Figure 1.

Figure 1.

Effect of AM4113 (1 mg/kg, i.p.) on alcohol drinking and anxiety-like behaviors in mice. (A) In a two-bottle free choice paradigm, AM4113 reduced consumption of 10% ethanol compared to vehicle treated group (*p<0.05; **p<0.01). (B) Bar graph shows the effect of AM4113 on mean alcohol intake (n=8-10 in each group). (C) In the light-dark box (LDB) exploration test, AM4113 treatment increased time spent exploring the light compartment compared to vehicle treatment. (*p<0.05). (D) AM4113 had no effect on general activity as entries to the dark compartment do not differ between AM4113-treated and vehicle-treated mice (n=11-12 in each group). Overall values are represented as mean ± SEM and individual values are shown with open circles.