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. Author manuscript; available in PMC: 2022 Sep 11.
Published in final edited form as: Chem Commun (Camb). 2021 Aug 11;57(70):8762–8765. doi: 10.1039/d1cc03073f

Figure 1.

Figure 1.

The pikromycin PKS and triketide synthases engineered from it. Each polyketide assembly line is colored using the updated module boundary (the traditional boundary is upstream of the KS domain). The pikromycin PKS generates narbonolide, the carbon scaffold of pikromycin, while the engineered synthases, Pik127 and Pik167, are anticipated to produce the triketide enantiomers, 1 and 2, respectively. Unlabeled circles and half-circles represent acyl carrier protein (ACP) domains and docking domain (DD) motifs, respectively. The twofold symbol indicates that modular PKSs are homodimeric.