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. Author manuscript; available in PMC: 2022 Sep 7.
Published in final edited form as: Chem Soc Rev. 2021 Jul 22;50(17):9794–9816. doi: 10.1039/d1cs00017a

Fig 2.

Fig 2.

Fig 2.

Fig 2.

a Different type of KIs. Structure of Src with kinase inhibitors in active (b, PDB: 3G5D), DFG-out (c, PDB: 4YBJ) and C-helix-out conformation (d, PDB: 4YBK). Type II inhibitors lead to DFG-out (dark blue) in contrast to DFG-in (light blue) conformation. c-Helix-out inhibitors lead to αC-helix-out (orange) in contrast to αC-helix in (red) conformation. Small molecule ligands are excluded for simplicity.