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. Author manuscript; available in PMC: 2022 Sep 7.
Published in final edited form as: Chem Soc Rev. 2021 Jul 22;50(17):9794–9816. doi: 10.1039/d1cs00017a

Fig 4.

Fig 4.

Gray’s hybridization concept to convert type I inhibitors into type II by conjugating ATP-binding active site fragment with a fragment with complementary hydrophobic pocket on inactive states.