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. 2021 Sep 1;11:17495. doi: 10.1038/s41598-021-96815-5

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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The effects of losartan and mirabegron on the echocardiographic parameters at week 13. (a) Representative M-mode images, (b) ejection fraction (EF), (c) diastolic septal mitral annulus velocity (e'), (d) posterior wall thicknesses in systole (PWTs) and (e) diastole (PWTd), (f) septal wall thickness in systole (SWTs) and (g) diastole (SWTd). Values are presented as mean ± S.E.M., *p < 0.05 vs. sham-operated group, ^#p < 0.05 vs. CKD group (n = 7–10, One-Way ANOVA, Holm-Sidak post hoc test), ^$p < 0.05 vs. week 4 in the same group (n = 7–10, Two-ways repeated-measures ANOVA, Holm-Sidak post hoc test). Sham sham-operated group, CKD chronic kidney disease group, CKD + L losartan-treated chronic kidney disease group, CKD + M mirabegron-treated chronic kidney disease group. Representative M-mode images were saved from the EchoPac Dimension v201 software.