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. 2021 Sep 1;11:17495. doi: 10.1038/s41598-021-96815-5

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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The effects of losartan and mirabegron on the protein expression at week 13 assessed by Western blot. Left ventricular expression and cropped representative images of (a) beta-3 adrenergic receptor (β3-AR), (b) endothelial nitric oxide synthase (eNOS), (c) phospho-eNOS, (d) phospho-eNOS/ eNOS ratio, (e) sarcoendoplasmic reticulum calcium ATPase 2a (SERCA2a), (f) phospholamban (PLN), (g) phospho-PLN (pPLN), and (h) phospho-PLN/PLN ratio. Values are presented as mean ± S.E.M., *p < 0.05 vs. sham-operated group, ^#p < 0.05 vs. CKD group (n = 6–7, One-Way ANOVA, Holm-Sidak post hoc test). Sham sham-operated group, CKD chronic kidney disease group, CKD + L losartan-treated chronic kidney disease group, CKD + M mirabegron-treated chronic kidney disease group. Images were captured with the Odyssey CLx machine and exported with Image Studio 5.2.5 software. The full-length Western blots are presented in Supplementary Figures S1-12.