Table 1.
Serum and total blood count parameters at week 13.
| Parameter (unit) | Groups | |||
|---|---|---|---|---|
| Sham | CKD | CKD + losartan | CKD + mirabegron | |
| Serum sodium ion (mmol/L) | 141 ± 0.7 | 140 ± 0.43 | 141 ± 0.62 | 141 ± 0.74 |
| Serum potassium ion (mmol/L) | 5.3 ± 0.16 | 4.97 ± 0.17 | 5.53 ± 0.15 | 5.23 ± 0.31 |
| Serum chloride ion (mmol/L) | 103 ± 0.95 | 103 ± 0.51 | 102 ± 0.45 | 101 ± 1.07 |
| Serum phosphate ion (mmol/L) | 2.28 ± 0.15 | 2.31 ± 0.1 | 2.22 ± 0.06 | 2.46 ± 0.13 |
| Serum calcium ion (mmol/L) | 2.44 ± 0.01 | 2.54 ± 0.04* | 2.58 ± 0.02* | 2.59 ± 0.02* |
| Serum magnesium ion (mmol/L) | 0.9 ± 0.02 | 0.97 ± 0.04 | 1.03 ± 0.04 | 1.29 ± 0.12*# |
| Serum total cholesterol (mmol/L) | 1.56 ± 0.03 | 2.23 ± 0.2* | 2.65 ± 0.12* | 4.11 ± 0.22*# |
| Serum LDL-cholesterol (mmol/L) | 0.53 ± 0.04 | 0.79 ± 0.08* | 0.73 ± 0.03* | 1.16 ± 0.11*# |
| Serum triglyceride (mmol/L) | 0.52 ± 0.03 | 0.6 ± 0.07 | 0.77 ± 0.12 | 0.99 ± 0.1*# |
| Red blood cells (1012/L) | 8.3 ± 0.11 | 7.25 ± 0.23* | 7.09 ± 0.22* | 6.55 ± 0.32* |
| Hematocrit (%) | 44 ± 1 | 39 ± 1* | 39 ± 1* | 36 ± 1*# |
| Hemoglobin (g/L) | 148 ± 2.29 | 131 ± 4.2* | 131 ± 2.26* | 120.14 ± 4.58* |
| White blood cells (109/L) | 3.45 ± 0.23 | 6.63 ± 0.87* | 4.47 ± 0.45# | 6.57 ± 0.6* |
Values are presented as mean ± S.E.M., *p < 0.05 vs. sham-operated group, #p < 0.05 vs. CKD group (n = 6–10 for serum parameters, n = 5–8 for blood count parameters, One-Way ANOVA, Holm-Sidak post hoc test).
Sham sham-operated group, CKD chronic kidney disease group.