Table 4.
Multivariable logistic regression analysis to evaluate the effects of cerebral small vessel disease on unfavorable outcome (mRS 3–6).
| Crude OR (95% CI) |
P-value | Adjusted OR (95% CI) |
P-value | |
|---|---|---|---|---|
| Model 1 | ||||
| Age | 1.00 [0.97–1.03] | 0.735 | 1.01 [0.96–1.07] | 0.601 |
| Sex | 0.52 [0.28–0.98] | 0.043 | 0.70 [0.26–1.90] | 0.481 |
| Systemic metastasis | 4.00 [2.09–7.65] | < 0.001 | 2.82 [1.03–7.72] | 0.044 |
| Adenocarcinoma | 3.06 [1.54–6.06] | 0.001 | 1.67 [0.63–4.44] | 0.302 |
| Initial NIHSS score | 1.32 [1.20–1.45] | < 0.001 | 1.27 [1.10–1.47] | 0.001 |
| Fasting glucose* | 3.92 [1.09–14.16] | 0.037 | 1.78 [0.35–8.97] | 0.484 |
| High-sensitivity CRP* | 1.70 [1.39–2.07] | < 0.001 | 1.34 [0.99–1.80] | 0.058 |
| D-dimer* | 2.38 [1.76–3.20] | < 0.001 | 1.24 [0.81–1.89] | 0.318 |
| Multiple territory lesion | 5.25 [2.72–10.13] | < 0.001 | 3.01 [1.10–8.19] | 0.031 |
| Silent brain infarct | 2.07 [1.09–3.92] | 0.027 | 1.57 [0.52–4.68] | 0.422 |
| Model 2† | ||||
| Severe WMH | 0.71 [0.34–1.51] | 0.376 | 1.69 [0.46–6.22] | 0.431 |
| Model 3† | ||||
| Cerebral microbleeds | 0.43 [0.21–0.88] | 0.022 | 0.33 [0.10–1.08] | 0.067 |
mRS = modified Rankin Scale, NIHSS = National Institutes of Health Stroke Scale, CRP = c-reactive protein, WMH = white matter hyperintensity.
*These variables were transformed using a log scale.
†Adjusted for age and P < 0.05 in univariate analysis (sex, systemic metastasis, adenocarcinoma, initial NIHSS score, fasting glucose, high-sensitivity CRP, D-dimer, and multiple territory lesion).