Fig. 1. Design of BBI-based antibacterial peptides.

a A general schematic of Bowman–Birk Inhibitor structure. b The peptide exists in a hairpin loop conformation due to formation of disulfide bridge between the loop-flanking cysteines. c The structural elements of the peptides as observed in crystal structures. SFTI-PDB ID:1SFI, HVBBI-PDB ID:4U2W. d Schematic representation of a cationic peptide structure (Moricin-PDB ID:1KV4). Loop region is indicated by red, cysteines are colored yellow, tail region is colored blue, and cationic residues in the tail region are colored pink.