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. 2021 Sep 1;12:5218. doi: 10.1038/s41467-021-25475-w

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — a View of the ¹¹⁴RVVSWF¹¹⁹ six-residue peptide linker in the CD47^BRIL-B6H12 crystal structure (green cartoon and sticks), and the insertion site of the ¹¹⁷SWF¹¹⁹ loop in the ECLR core. The ECD is shown as green cartoon and the TMD helices are colored blue (helix I), light green (helix II), orange (helix III) and light orange (helix V). The ECL1 is shown as orange cartoon and sticks. b A 90 degree rotation of CD47^BRIL-B6H12 structure view shown in (a) highlighting the ECL1 hydrogen bonds (black dotted lines) between Y184 side chain and ECL2 (main-chain atoms shown as gray sticks and labeled), and between N188 side chain and ECL1 (orange sticks).