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. 2021 Sep 1;11:17529. doi: 10.1038/s41598-021-96470-w

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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CNVs, mutations, and SNVs of m5C regulatory genes in PAAD. A total of 363 PAAD patients from TCGA were analyzed. (A) Mutation frequencies in m5C regulatory genes with indicated functions. (B) Mutation sites in DNMT3A. (C) Seven functionally altered genes and patient survival. P value did not reach significance due to the small number of mutations. (D) CNV statistics of m5C regulatory genes in PAAD samples. Writers accounted for 81.69%, which was highest. Readers and erasers made up almost the same proportion at approximately 9%.