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. 2021 Sep 1;11:17529. doi: 10.1038/s41598-021-96470-w

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Relationship between m5C regulatory gene expression and patient prognosis, with DNMT3A gene functional enrichment analysis. The impact of 13 m5C regulatory genes on patient prognosis using multivariate Cox regression. (A, B) Multivariate Cox regression of survival (P < 0.001) and AUC curves (AUC curve areas > 0.65). (C) Relationship between DNMT3A expression and patient prognosis (P = 0.036). (D–F) GSEA enrichment analysis of the DNMT3A Gene showing low DNMT3A expression related to ribosomal processing.