Table 1.

Studies that have compared the EGJ-CI among patient and control populations. Methods of EGJ-CI computation in instances of LES-CD separation were not uniform among these studies, with some including and some excluding the CD component. Functional patients were defied as having reflux symptoms, but normal physiological studies.

	Median [IQR] EGJ-CI in mmHg•cm
Study	Control Subjects	GERD	Functional
Nicodème 2014	39 [25–55] n=75	18* [8–30] n=7	45 [23–67] n=45
Tolone 2015	-----	11* [3–21] n=91	22 [10–41] n=39
Jasper 2016	63 [50–90] n=63	50* [28–70] n=116	-----
Wang 2016	35 [26–58] n=21	30* [15–53] n=68	-----
Xie 2017	63 [38–83] n=21	22* [20–31] n=39† 26* [15–38] n=38§	30* [19–44]
Ham 2017	67 [27–79] n=23	28* [4–63] n=25† 26* [15–32] n=16§	51 [3–153] ¶

^*p<0.05 vs controls or comparator;

^†esophagitis patients;

^§Non-erosive reflux disease;

^¶non-GERD