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. Author manuscript; available in PMC: 2021 Sep 25.
Published in final edited form as: Eur Respir J. 2021 Sep 23;58(3):2002012. doi: 10.1183/13993003.02012-2020

Table 2.

The effect of prenatal vitamin D3 supplementation on the development of asthma/recurrent wheeze by age 0–3 years stratified by maternal 17q21 genotype.

Mother rs12936231 genotype VDAART COPSAC2010
Cases/Total HR (95% CI) P value Cases/Total HR (95% CI) P value
GG/GC* 127/431 0.54 (0.37–0.77) <0.001 70/415 0.56 (0.35–0.92) 0.021
GG 34/132 0.39 (0.18–0.83) 0.015 25/152 0.51 (0.22–1.18) 0.117
GC 93/299 0.58 (0.39–0.88) 0.011 45/263 0.59 (0.33–1.08) 0.086
CC 50/182 1.05 (0.61–1.84) 0.853 30/148 1.11 (0.54–2.28) 0.785
*

Combined maternal GG-genotype and GC-genotype.

Analyses were performed using Cox proportional hazard regression. G is considered as the dominant low-risk allele and C the recessive high-risk allele.