Table 3.

Multivariable models^† for the interaction between maternal 17q21 genotype and prenatal vitamin D₃ supplementation on the risk of offspring asthma/recurrent wheeze at 0–3 years.

	VDAART (n=613)		COPSAC2010 (n=563)
	Estimate	P value	Estimate	P value
Additive model
Mother rs12936231 genotype	−0.03	0.321	−0.02	0.514
Vitamin D3 intervention	−0.20	0.002	−0.13	0.015
Mother rs12936231 genotype*Vitamin D3 intervention	0.10	0.048	0.08	0.070
Dominant model
Mother rs12936231 genotype	−0.09	0.112	−0.04	0.445
Vitamin D3 intervention	−0.14	0.001	−0.09	0.016
Mother rs12936231 genotype*Vitamin D3 intervention	0.15	0.059	0.14	0.053

^†For VDAART, the model was: asthma/recurrent wheeze ^~ mother genotype*vitamin D₃ intervention + child sex + child race + study site. For COPSAC₂₀₁₀, the model was: asthma/recurrent wheeze ^~ mother genotype*vitamin D₃ intervention + child sex + fish oil intervention.

The additive model compares maternal genotypes GG vs. GC vs. CC and the dominant model compares maternal genotypes GG/GC vs. CC.