Table 4.
The effect of prenatal vitamin D3 supplementation on the development of early life asthma/recurrent wheeze stratified by maternal and offspring 17q21 genotype combinations.
| VDAART | COPSAC2010 | ||||||
|---|---|---|---|---|---|---|---|
| Mother rs12936231 genotype | Child rs12936231 genotype | Cases/Total | HR (95% CI) | P value | Cases/Total | HR (95% CI) | P value |
| GG/GC* | GG/GC* | 91/324 | 0.54 (0.35–0.83) | 0.005 | 47/316 | 0.57 (0.31–1.02) | 0.060 |
| GG | GG | 11/68 | 0.26 (0.06–1.20) | 0.083 | 11/70 | 0.43 (0.11–1.62) | 0.212 |
| GG | GC | 23/64 | 0.44 (0.18–1.06) | 0.068 | 10/68 | 0.68 (0.19–2.42) | 0.554 |
| GC | GG | 11/55 | 0.54 (0.17–1.77) | 0.311 | 7/62 | 0.41 (0.08–2.10) | 0.282 |
| GC | GC | 46/137 | 0.69 (0.39–1.25) | 0.222 | 19/116 | 0.64 (0.26–1.59) | 0.334 |
| GC | CC | 23/74 | 0.60 (0.26–1.36) | 0.218 | 16/57 | 0.65 (0.24–1.74) | 0.391 |
| CC | GC | 23/82 | 1.02 (0.45–2.32) | 0.966 | 10/67 | 0.80 (0.23–2.76) | 0.723 |
| CC | CC | 22/85 | 1.16 (0.50–2.68) | 0.731 | 16/62 | 1.60 (0.58–4.41) | 0.362 |
*
Combined GG-genotype and GC-genotype.
Analyses were performed using Cox proportional hazard regression. G is considered as the dominant low-risk allele and C as the recessive high-risk allele.