Table 5.
The effect of prenatal vitamin D3 supplementation on the development of early life asthma/recurrent wheeze stratified by maternal and child 17q21 genotype in African Americans and in other races from VDAART.
| African American (n=262) | Other races* (n=351) | ||||||
|---|---|---|---|---|---|---|---|
| Cases/Total | HR (95% CI) | P value | Cases/Total | HR (95% CI) | P value | ||
| Mother rs12936231 genotype | |||||||
| GG/GC† | 67/182 | 0.55 (0.33–0.90) | 0.018 | 60/249 | 0.54 (0.33–0.91) | 0.021 | |
| GG | 24/67 | 0.24 (0.09–0.65) | 0.005 | 10/65 | 0.82 (0.23–2.89) | 0.750 | |
| GC | 43/115 | 0.82 (0.45–1.50) | 0.520 | 50/184 | 0.46 (0.26–0.82) | 0.008 | |
| CC | 27/80 | 1.12 (0.52–2.39) | 0.770 | 23/102 | 0.86 (0.37–1.98) | 0.720 | |
| Mother rs12936231 genotype | Child rs12936231 genotype | ||||||
| GG/GC† | GG/GC† | 54/145 | 0.54 (0.31–0.96) | 0.035 | 37/179 | 0.58 (0.30–1.12) | 0.100 |
| GC | CC | 9/25 | 0.89 (0.24–3.33) | 0.870 | 14/49 | 0.47 (0.17–1.35) | 0.160 |
| CC | GC | 13/38 | 1.07 (0.36–3.18) | 0.910 | 10/44 | 0.75 (0.19–2.89) | 0.670 |
| CC | CC | 11/34 | 1.64 (0.48–5.61) | 0.430 | 11/51 | 0.81 (0.25–2.66) | 0.730 |
*
Other races included: Caucasian (n=251), Asian (n=26), American Indian or Alaska Native (n=8), Native Hawaiian or Other Pacific Islander (n=8), and other races (n=58).
†
Combined GG-genotype and GC-genotype.
Analyses were performed using Cox proportional hazard regression. G is considered as the dominant low-risk allele and C as the recessive high-risk allele.