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. 2021 Sep 1;11:15523. doi: 10.1038/s41598-021-93967-2

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Histogram for the distribution of DLS predicted scores across 6 datasets and their corresponding operating point selection sets: (A) DS-1 and CXR-14, (B) TB-1 and TB-2, and (C) COV-1 and COV-2. Curation of the operating point selection (Op. Sel.) datasets is described in “Operating point selection datasets” in “Methods”. Positive and negative examples are visualized separately in red and blue, respectively. The vertical lines (black) highlight the selected high-sensitivity operating point for each scenario.