Table 1.

Expression and process regulated by of purinergic elements in lung cancer

Lung cancer
Purinergic element	Effect	Model	References
P2YRs	Activation of the Gq/PLC/ Ca2+ pathway	A549 cell line	[21]
P2Y2R and P2Y6R	Increase in cell proliferation	A549 cell line	[22]
P2X4R	Expression of this receptor, role not elucidated	A549 cell line	[23]
P2Y2R	ATP and mucin release after P2Y2R activation	Calu-3 cell line	[24]
P2X7R	Increased expression in tumoral cells	A549, PC-9 and H292 cell lines Biopsies from NSCLC patients	[25–27]
P2X7R	Decreased expression and higher cell survival by regulation of [Ca2+]i /Bcl-2/Bax ratio	A549 and H23 cell lines	[28, 29]
P2X7R	JNK and Rho kinase activation, cell migration	H292 cell line	[26]
P2X7R	EMT transition	A549 cell line	[30]
P2X7R	Receptor inhibition with A438079, decreased cell migration	HTB183 and HTB177 cell lines	[31]
P2X7R	Receptor inhibition with AZ10606120, decreased cell proliferation	A549 cell line	[25]
AdoR2B	Angiogenesis promoter, immune response suppressor	Lewis lung carcinoma isograft model	[32]
AdoR2B	Regulation of EMT	Human epithelial lung cells	[33]
AdoR3	Decreased cell proliferation apoptosis induction	A549 cell line	[34]