TABLE 4.

Examples of receptors and preferential tissue tropism of natural AAV vectors (Reproduced, with permission, from Costa Verdera, p 3, Table 1)

Serotype	Source	Glycan Receptor	Co‐Receptor/Other	Examples of Tissue Tropism
AAV1	Nonhuman primate	N‐linked sialic acid	Unknown	Skeletal muscle, lung, CNS, retina, pancreas
AAV2	Human	HSPG	FGFR1, HGFR, LamR, CD9, tetraspanin	Smooth muscle, skeletal muscle, CNS, liver, kidney
AAV3	Nonhuman primate	HSPG	FGFR1, HGFR, LamR	Hepatocarcinoma, skeletal muscle, inner ear
AAV4	Nonhuman primate	O‐linked sialic acid	Unknown	CNS, retina
AAV5	Human	N‐linked sialic acid	PDGFR	Skeletal muscle, CNS, lung, retina, liver
AAV6	Human	N‐linked sialic acid, HSPG	EGFR	Skeletal muscle, heart, lung, bone marrow
AAV7	Nonhuman primate	Unknown	Unknown	Skeletal muscle, retina, CNS
AAV8	Nonhuman primate	Unknown	LamR	Liver, skeletal muscle, CNS, retina, pancreas, heart
AAV9	Nonhuman primate	N‐linked galactose	LamR	Liver, heart, brain, skeletal muscle, lung, pancreas, kidney
AAV10	Nonhuman primate	Unknown	Unknown	Liver

Abbreviations: AAV, adeno‐associated virus; CNS, central nervous system; EGFR, epidermal growth factor receptor; FGFR1, fibroblast growth factor receptor 1; HGFR, hepatocyte growth factor; HSPG, heparan sulfate proteoglycans; LamR, laminin receptor; PDGFR, platelet‐derived growth factor receptor.