Table 2. Demographic characteristics of human AGA and FGR study participants.
| Term delivery | Preterm delivery | P-value | |||
|---|---|---|---|---|---|
| AGA | Late-onset FGR | Early-onset FGR | Early-onset FGR | ||
| n=15 | n=8 | n=4 | n=17 | ||
| Maternal age (years) | 38.0 (31.0–39.0) | 32.5 (31.0–34.8) | 32.0 (25.3–39.5) | 35.0 (31.0–39.5) | 0.4591 |
| Maternal BMI (kg/m2) | 23.0 (22.0–28.0) | 22.0 (22.0–31.0) | 23.0 (21.5–32.0) | 24.0 (23.0–28.0) | 0.4452 |
| Ethnicity (number Asian, Black or Mixed) | 2 (13%) | 6 (75%) | 1 (25%) | 5 (29%) | 0.0253 |
| Hypertensive disorder of pregnancy (number with any diagnosis) | 0 (0%) | 1 (13%) | 1 (25%) | 7 (41%) | 0.0343 |
| Fetal sex (number male) | 10 (67%) | 4 (50%) | 1 (25%) | 6 (35%) | 0.2563 |
| Mode of delivery (number vaginal) | 4 (27%) | 1 (13%) | 2 (50%) | 1 (6%) | 0.1483 |
| Gestational age (weeks) | 39.1 (39.0–39.6) | 37.5 (36.9–38.5 | 38.4 (37.6–40.5) | 28.05 (27.1–31.0) | <0.0012 |
| Placental weight (g)6 | 491 (428–521) | 3514 (240–365) | 584 | 1425 (135–185) | <0.0011 |
Continuous variables are given as median (interquartile range) and compared by one-way ANOVA1 with Sidak’s multiple comparison post-hoc or by Kruskal–Wallis test2 with Dunn’s multiple comparison post-hoc. 4Significantly different from AGA, 5significantly different from early-onset FGR delivered at term. Categorical variables are given as number (% of n) and compared by chi-squared test3.
6Placental weights were collected for a subset of study participants: AGA n=9, late-onset FGR n=6, term early-onset FGR n=1, preterm early-onset FGR n=5.