Table 2. Correlation coefficients and the corresponding P-values showing the relationships between immune cell frequencies in the sputum and the alpha-diversity of the microbial communities in the airway in HC and asthma patients.

Alpha diversity in sputum	Immune cells	Correlation Coefficient				p-value				p-value (adjusted)
		HC	Non-severe	Severe	All	HC	Non-severe	Severe	All	HC	Non-severe	Severe	All
Simpson Index	Total ILCs	−0.0254	−0.3046	−0.2118	−0.2153	0.9377	0.2345	0.3204	0.1216	0.9377	0.7035	0.4806	0.4809
Shannon Index	Total ILCs	0.0972	−0.3322	−0.4063	−0.2734	0.7637	0.1927	0.0488	0.0476	0.9377	0.7035	0.3134	0.4809
Simpson Index	NCR−ILC3s	−0.2054	−0.2686	−0.1700	−0.1842	0.5218	0.2972	0.4272	0.1868	0.9377	0.7877	0.5243	0.4809
Shannon Index	NCR−ILC3s	−0.0851	−0.3454	−0.2621	−0.1898	0.7926	0.1746	0.2161	0.1735	0.9377	0.7035	0.4405	0.4809
Simpson Index	NCR+ILC3s	0.0723	−0.2562	−0.4402	−0.1254	0.8233	0.3209	0.0313	0.3711	0.9377	0.7877	0.3134	0.5893
Shannon Index	NCR+ILC3s	0.2640	−0.1991	−0.3515	0.0037	0.4070	0.4436	0.0921	0.9792	0.9377	0.7899	0.3134	0.9792
Simpson Index	M1	−0.0957	−0.3135	−0.1920	−0.2059	0.7674	0.2204	0.3688	0.1390	0.9377	0.7035	0.5241	0.4809
Shannon Index	M1	−0.0470	−0.1888	−0.3508	−0.2210	0.8846	0.4681	0.0929	0.1117	0.9377	0.7899	0.3134	0.4809
Simpson Index	M2	−0.0265	−0.1002	−0.1141	−0.0842	0.9349	0.7019	0.5954	0.5487	0.9377	0.8390	0.6698	0.7408
Shannon Index	M2	0.0940	−0.0212	−0.1210	−0.0365	0.7714	0.9356	0.5734	0.7952	0.9377	0.9356	0.6698	0.8912
Simpson Index	AM	0.0293	−0.2318	−0.0953	−0.0889	0.9280	0.3708	0.6577	0.5265	0.9377	0.7899	0.7046	0.7408
Shannon Index	AM	0.1114	−0.1506	−0.2228	−0.0941	0.7304	0.5639	0.2954	0.5028	0.9377	0.8013	0.4692	0.7408

The coefficients were calculated both separately for each patient/control group and for all subjects.

Non-severe, patients with non-severe asthma; Severe, patients with severe asthma.