Table 3.

Summary of associations between circRNAs and diagnosis and prognosis in TNBC

circRNA	Study (year) reference	Length	Source	Clinical stage relatedness	Prognosis
circSEPT9	Zheng et al. (2020)76	645 bp	4 pairs of tumor and adjacent noncancerous tissues	circSEPT9 positively correlated with TNM stage, metastasis, and chemoresistance	high circSEPT9 predicted a poor prognosis
circUBE2D2	Dou et al. (2020)84	280 bp	66 pairs of tumor tissues	circUBE2D2 positively correlated with TNM stage, lymph node metastasis, and chemoresistance	high circUBE2D2 predicted a poor prognosis
circHER2	Li et al. (2020)98	676 bp	59 patients	circHER2 positively correlated with tumor grade and metastasis	high circHER2 predicted a poor prognosis
circAGFG1	Yang et al. (2019)99	527 bp	4 pairs of tumor tissues	circAGFG1 positively correlated with tumor grade, pathological grade, and lymph node invasion	high circAGFG1 predicted poor OS
circKIF4A	Tang et al. (2019)100	355 bp	240 tumor tissues	circKIF4A positively correlated with tumor grade, lymph node invasion, and metastasis	high circKIF4A predicted poor OS and DFS
circPLK1	Kong et al. (2019)101	1,708 bp	240 tumor tissues	circPLK1 positively correlated with tumor grade, invasion, lymph node stage, and metastasis	high circPLK1 predicted poor OS and DFS
circRNA_069718	Zhang et al. (2019)89	590 bp	35 pairs of tumor tissues	circRNA_069718 positively correlated with lymph node stage and metastasis	high circRNA_069718 predicted poor OS
circRAD18	Zou et al. (2019)82	756 bp	126 tumor tissues	circRAD18 positively correlated with T stage, clinical stage, and pathological grade	high circRAD18 predicted poor OS
circANKS1B	Zeng et al. (2018)83	459 bp	165 tumor tissues	circANKS1B positively correlated with lymph node stage and metastasis	high circANKS1B predicted poor OS
circEPSTI1	Chen et al. (2018)143	375 bp	240 tumor tissues	circEPSTI1 positively correlated with tumor grade, invasion, lymph node stage, and metastasis	high circEPSTI1 predicted poor OS and DFS
circUBAP2	Wang et al. (2018)144	747 bp	78 tumor tissues	circUBAP2 positively correlated with tumor size, TNM grade, lymph node invasion, and metastasis	high circUBAP2 predicted poor OS
circGFRA1	He et al. (2017)85/Zheng et al. (2021)86	427 bp	222 tumor tissues	circGFRA1 positively correlated with tumor grade, lymph node invasion, and metastasis	high circGFRA1 predicted poor OS and DFS
circNR3C2	Fan et al. (2021)145	1,759 bp	70 tumor tissues	circNR3C2 negatively correlated with tumor growth and metastasis	low circNR3C2 predicted poor prognosis
circITCH	Wang et al. (2019)146	NA	91 tumor tissues	circITCH negatively correlated with tumor grade, lymph node invasion, and metastasis	low circITCH predicted poor OS
circTADA2A-E6	Xu et al. (2019)103	158 bp	121 tumor tissues	circTADA2A-E6 negatively correlated with lymph node invasion and metastasis	low circTADA2A-E6 predicted poor DFS
circFBXW7	Ye et al. (2019)94	1,227 bp	473 tumor tissues	circFBXW7 negatively correlated with tumor grade and lymph node invasion	low circFBXW7 predicted poor OS and DFS

OS, overall survival; DFS, disease-free survival; LIF, leukemia inhibitory factor; NA, not applicable.