Table 5.
Biomedical activity and application of saccharolipids
| Subclass | Name | Activity | Medical application | Ref. |
|---|---|---|---|---|
| Lipid A | LPS | Upregulation of pro-inflammatory cytokines | Wound healing | Kostarnoy et al., 2013 |
| Generate tolerogenic dendritic cells to exhaust effector CD4 T cells | Experimental autoimmune encephalomyelitis | Zhou et al., 2014 | ||
| Increase endogenous TNF-α expression | Cancer | Goto et al., 1996 | ||
| Upregulation of MHC molecule on GSCs | Cancer | Han et al., 2017 | ||
| Monophosphoryl lipid A | TLR4 agonist | Vaccine adjuvant | Saito et al., 2010 | |
| Enhancing CD4 T cell activation and initial clonal expansion | Vaccine adjuvant | Thompson et al., 2005 |