Fig. 5.

The effect of MMP-8i on motor behavior in LRRK2 G2019S mice using the rota-rod test and the open field test. (A) Latency to fall was detected to evaluate motor coordination in the rota-rod test. (B) Rearing was counted in the open field test to detect general activity. (C) Time spent in the center was counted in the open field test to detect anxiety-like activity (ANOVA F=10.980, p=0.008) (*p<0.05, between the MMP-8i and vehicle (Veh) injection groups; ^§p<0.05, between MT and LM mice). Data are expressed as the mean ± SEM of four independent experiments.