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Mutator phenotypes of diploids heterozygous for mlh1 mutations
| Genotype | Lys+ reversion
|
|
|---|---|---|
| Reversion rate (10−8)a | Fold increase | |
| MLH1/MLH1 | 16 (12–20) | 1 |
| MLH1/mlh1Δ | 90 (73–200) | 5.8 |
| MLH1/mlh1-P25L | 56 (37–160) | 3.7 |
| MLH1/mlh1-M32R | 43 (38–65) | 2.7 |
| MLH1/mlh1-G64R | 97 (68–200) | 6.1 |
| MLH1/mlh1-I65N | 120 (98–270) | 7.6 |
| MLH1/mlh1-T114M | 74 (44–100) | 4.6 |
| MLH1/mlh1-G243D | 110 (93–220) | 6.8 |
Median for 9 to 18 independent determinations, with 95% confidence limit in parentheses.
