Effects of ZEB1 loss in astrocytes
(A) Representative images at 4 weeks post-induction, identifying SOX9+ SGZ astrocytes (insets).
(B) Representative images at 8 weeks post-induction, identifying S100β+ SGZ astrocytes (arrows).
(C) Quantification of SOX9+tdTOM+ non-RGL astrocytes in the SGZ (left) at 4 and 8 weeks post-induction and of S100β+tdTOM+ SGZ astrocytes (right) at 8 and 12 weeks post-induction.
(D) Quantification of SOX9+tdTOM+ (left) and S100β+tdTOM+ (right) astrocytes in the DG.
(E) Fraction of apoptotic GFAP+ RGL at 1 day post-induction.
(F) Fraction of SOX9+ apoptotic astrocytes at 4 weeks post-induction.
Dots represent individual mice (minimum of two sections analyzed per animal); numerical data are shown as mean ± SEM. Scale bars: 20 μm (insets: 10 μm).