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Kaplan-Meier estimate of PFS. (A) Kaplan-Meier estimate of PFS subgroups by duration of denosumab and ICI overlap (6.0 vs. 1.9 months P=0.0005). (B) Kaplan-Meier estimate of PFS subgroups by brain metastases (3.9 vs. 2.1 months, P=0.2). (C) Kaplan-Meier estimate of PFS subgroups by line of therapy i.e., first line vs. second line (4.3 vs. 1.8 months, P=0.006). (D) Kaplan-Meier estimate of PFS subgroups by skeletal metastases (3.7 vs. 2 months, P=0.1). ICI, immune checkpoint inhibitor.
