TABLE 1.

Summary of pregabalin withdrawal in cases taking a regular dose of pregabalin

Case report citation	Case	Psychiatric disorders	PGB maximum dosage	PGB duration	Discontinuation or taper period	Onset of symptoms after discontinuation of PGB	Withdrawal symptoms
							Psychopathologic symptoms	Vegetative symptoms	Neurologic and physical complications
Uçar 20208	30 F	None	150 mg/d	45 days	Discontinuation	48 hours	Insomnia, dysphoria, delusions, visual hallucinations, and the idea of harm	ND	ND
Naveed 20189	62 F	GAD and DD	450 mg/d	ND	ND	ND	Anxiety, fear, insomnia, suicidal ideations, and feeling of going crazy.	Tremors, dyspnea, palpitations, and dizziness.	Chest pain, extreme weakness of legs, and aches.
Du 201710	52 F	None	150 mg/d	Many years	Discontinuation	4 days	ND	ND	Tonic‐clonic seizure
Driot 201611	24 F	GAD, DD, PD, and anorexia	300 mg/d	A few weeks	No tapering or discontinuation	ND	Asthenia, insomnia, and suicidal ideas	Tremors, sweating	ND
Gahr 201312	38 F	PD and DD	600 mg/d	2 months	25 mg/d	10 days	Psychomotor agitation and craving	Hypertension, tachycardia, and tremor	ND
Oaklander 200513	80 F	None	375 mg/d	49 weeks	0	30 hours	Visual and auditory hallucinations, alexia, distorted color perception, delirium, terror	ND	Nausea, headache, “imbalance,”
Case 1	39 M	None	600 mg/d	2 months	0	2 days	Insomnia, anxiety, and restlessness	Palpitations	difficulty in breathing, and loss of appetite
Case 2	74 F	None	150 mg/d	10 years	0	7 days	Insomnia, depressed mood, anxiety, restlessness, suicidal ideation, and psychological discomfort	Tremor, cold sweats, lacrimation	Physical discomfort, headache, appetite loss, dyspnea, and epigastric discomfort
Case 3	69 M	None	600 mg/d	19 years	0	1 day	Insomnia and depressed mood	None	Chest tightness, suffocation, chills, and loss of appetite

Abbreviations: DD, depressive disorder; GAD, generalized anxiety disorder; ND, not described; PD, personality disorder; PGB, pregabalin.