FIGURE 1.

The effect of dams' breeders on prepulse inhibition after administering Poly(I:C) to their dams. The inhibitory effects of prepulse sounds at 73, 76, 79, and 82 dB were assessed as PPI levels in pups born to pregnant C57BL/6J mice after raising them for 2‐3 months. On gestation day 15, pregnant mice from CLEA Japan (A; n = 17 for saline and n = 39 for Poly(I:C) from 3 and 6 dams, respectively), Charles River Japan (B; n = 21 for saline and n = 14 for Poly(I:C) both from 3 dams), and SLC Japan (C; n = 27 for saline and n = 24 for Poly(I:C) both from 5 dams) were challenged with Poly(I:C) or saline. Data are presented as mean ± SEM. PPI was observed in the inhibitory % of the main pulse‐triggered startle. *P < .05, planned multiple comparison was performed between saline and Poly(I:C) groups at each prepulse levels using Welch t test with the Holm's compensation