Table 3.
Associations of Pericardial Adipose Tissue Volume and Abdominal Visceral Adipose Tissue Area With High-Attenuation Areas, Interstitial Lung Abnormalities, and FVC Within Prespecified Subgroups by Sex
| Subgroup | No. | Change in HAA per Doubling in PAT Volume | 95% CI | P for Interaction | No. | Change in ILA per Doubling in PAT Volume | 95% CI | P for Interaction | No. | Change in Percent Predicted FVC per Doubling in PAT Volume | 95% CI | P for Interaction |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Sex | < .001 | .01 | .18 | |||||||||
| Male | 3,144 | 47.6 | 36.8 to 58.5 | 1,125 | 1.5 | 1.1 to 2.0 | 722 | –6.7 | –8.3 to –5.0 | |||
| Female | 3,546 | 76.7 | 65.5 to 87.9 | 1,269 | 1.0 | 0.8 to 1.3 | 678 | –4.8 | –6.7 to –2.9 |
| Subgroup | No. | Change in HAA per Doubling in VAT Area | 95% CI | P for Interaction | No. | Change in ILA per Doubling in VAT Area | 95% CI | P for Interaction | No. | Change in Percent Predicted FVC per Doubling in VAT Area | 95% CI | P for Interaction |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Sex | .15 | .11 | .10 | |||||||||
| Male | 921 | 25.9 | 7.1 to 44.8 | 424 | 1.6 | 0.8 to 2.7 | 725 | –6.6 | –8.3 to –4.9 | |||
| Female | 917 | 52.5 | 33.9 to 71.2 | 420 | 1.1 | 0.7 to 1.8 | 679 | –4.9 | –6.6 to –3.3 |
Models adjusted for study site, age, height, race, smoking status, cigarette pack-years, study site, percent emphysema (FVC and HAA models), imaged lung volume (HAA models), and radiation dose (HAA model). HAA = high-attenuation area; ILA = interstitial lung abnormalities; PAT = pericardial adipose tissue; VAT = visceral adipose tissue.