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In vivo safety evaluation of PVES and PVES/mRNA vaccine. (A) Saline, PVES and PVES/mRNA (30 μg) were intramuscularly injected into mice at the dose of 180 μg for PVES. Cytokines in plasma were recorded at 6 h and 24 h post injection. (B) Body weight changes during the immune period. (C) H&E staining of liver, spleen, kidney pathology on 42 days post initial immunization. Scale bar, 200 μm.
