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. 2021 Aug 13;12:701383. doi: 10.3389/fimmu.2021.701383

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Copyright © 2021 Lin, Wei, Chen, Lim and Hwang

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Overview of neutrophil development and biological function. The production and maturation of neutrophils develop in bone marrow. After stress or inflammatory stimulation, neutrophils undergo a special recruitment cascade and eventually migrate into inflammatory tissues. Respiratory burst, degranulation, and NETs formation are the main mechanisms responsible for inflammation, leading to the elimination of the invading microorganisms or promoting the inflammatory response; CXCR, CXC-chemokine receptor; GMP, granulo-monocytic progenitor; NETs, neutrophil extracellular traps.