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. Author manuscript; available in PMC: 2021 Sep 2.
Published in final edited form as: Brain Behav Immun. 2017 Sep 22;68:34–43. doi: 10.1016/j.bbi.2017.09.013

Fig. 1.

Fig. 1.

Schematic representation of experimental layout. Wild type (CX3CR1+/+) and CX3CR1-deficient (CX3CR1−/−) mice were subjected to behavioral testing for anxiety-like behavior (elevated zero maze) on Day 1 (D1) followed by acoustic startle (D3) and then underwent a contextual fear conditioning paradigm (acquisition (D5) conditioned fear testing (D6) extinction (D6–D9) and fear reinstatement (D10). A separate cohort was subjected to anxiety-like behavior testing in the open field and light dark box to avoid repeated testing for anxiety-like behavior using different anxiety tests. Brains were collected for morphological assessment of cFos-like immunoreactivity and microglial activation.