FIGURE 1.

a, b) 7- and c, d) 14-day early bactericidal activity (EBA) (95% CI) of rifampicin based on a, c) CFU and b, d) time to positivity (TTP). Data from all patients were included with the exception of data from one patient from each of the 20 and 50 mg·kg⁻¹ groups that had consistent negative cultures at baseline and throughout. The slight change in the estimates for 10 and 20 mg·kg⁻¹ compared with previously [6] are because of data corrections (four CFU cultures were recorded as negative while they were actually missing).