| Study |
Bias |
| Randomisation process |
Deviations from intended interventions |
Missing outcome data |
Measurement of the outcome |
Selection of the reported results |
Overall |
| Authors' judgement |
Support for judgement |
Authors' judgement |
Support for judgement |
Authors' judgement |
Support for judgement |
Authors' judgement |
Support for judgement |
Authors' judgement |
Support for judgement |
Authors' judgement |
Support for judgement |
| Eom 2021 (40 mg/kg) |
Low risk of bias |
Participants were randomised via an Interactive Web Response System (IWRS) and the allocation sequence was concealed. There are no baseline differences that would suggest a problem with randomisation. |
Low risk of bias |
Both participants and those delivering the intervention were unaware of the intervention received. Participants with a negative PCR were excluded from analysis in both groups (intervention and placebo group) and one participant in the placebo arm did not receive the allocated intervention. The analysis was probably appropriate. |
Low risk of bias |
Data for this outcome was available for 307 out of 327 participants randomised. |
Low risk of bias |
The measurement of the outcome was appropriate and it is unlikely that it differed between intervention groups. The outcome assessors were unaware of the intervention received. |
Low risk of bias |
The data that produced this result was analysed in accordance with the pre‐specified analysis plan and the outcome was reported as planned in the protocol. |
Low risk of bias |
For this outcome, there is a low risk of bias for all the domains. |
| Eom 2021 (80 mg/kg) |
Low risk of bias |
Participants were randomised via an Interactive Web Response System (IWRS) and the allocation sequence was concealed. There are no baseline differences that would suggest a problem with randomisation. |
Low risk of bias |
Both participants and those delivering the intervention were unaware of the intervention received. Participants with a negative PCR were excluded from analysis in both groups (intervention and placebo group) and one participant in the placebo arm did not receive the allocated intervention. The analysis was probably appropriate. |
Low risk of bias |
Data for this outcome was available for 307 out of 327 participants randomised. |
Low risk of bias |
The measurement of the outcome was appropriate and it is unlikely that it differed between intervention groups. The outcome assessors were unaware of the intervention received. |
Low risk of bias |
The data that produced this result was analysed in accordance with the pre‐specified analysis plan and the outcome was reported as planned in the protocol. |
Low risk of bias |
For this outcome, there is a low risk of bias for all the domains. |
