Table 2.

Protein-MPV/PLT Association Analysis Results from FHS Data

Trait	Protein*	β‡	SE	Z-test p-value§
MPV	sCD40L†	−0.108	0.014	5.81E-14
	SDF1†	−0.108	0.015	2.47E-13
	PPBP†	−0.087	0.015	2.68E-09
	NOTCH1†	0.066	0.015	7.71E-06
	ADM†	0.066	0.015	9.74E-06
	GAPDH†	−0.064	0.014	9.74E-06
	MMP9	0.061	0.015	3.09E-05
	RETN	0.063	0.015	4.71E-05
	MPO	0.058	0.016	2.06E-04
	CDH13†	−0.050	0.015	5.63E-04
PLT	PPBP†	0.217	0.0150	2.80E-47
	sCD40L†	0.183	0.0150	2.99E-34
	PAI1	0.157	0.0151	2.09E-25
	GMP140	0.152	0.0155	9.78E-23
	sRAGE	−0.136	0.0158	8.42E-18
	GP5	0.128	0.0155	1.31E-16
	CNTN1	−0.122	0.0155	2.96E-15
	CDH13†	0.118	0.0152	6.95E-15
	LDLR	0.118	0.0152	9.69E-15
	GAPDH†	0.101	0.0152	2.96E-11
	NRCAM	0.0875	0.0150	5.87E-09
	PMP2	0.0878	0.0152	8.24E-09
	NOTCH1†	−0.0882	0.0155	1.17E-08
	SDF1†	0.0848	0.0156	5.33E-08
	KLKB1	0.0849	0.0157	6.72E-08
	CRP	0.0813	0.0151	6.82E-08
	ADAM15	0.0781	0.0151	2.40E-07
	CD56 (NCAM)	−0.0779	0.0156	6.50E-07
	ANGPTL3	0.0743	0.0152	1.09E-06
	HPX	0.0742	0.0153	1.29E-06
	ApoB	0.0731	0.0154	2.09E-06
	C2	0.0731	0.0154	2.19E-06
	AGP1	0.0713	0.0152	2.84E-06
	MCAM	−0.0715	0.0156	4.37E-06
	CD5L	−0.0640	0.0160	6.44E-05
	ADM†	−0.0615	0.0155	7.51E-05
	BGLAP	−0.0613	0.0155	7.65E-05
	FGG	0.0617	0.0158	9.30E-05
	BCHE	0.0592	0.0156	1.53E-04
	NTproBNP	−0.0591	0.0157	1.70E-04
	A1M	0.0589	0.0161	2.50E-04

^*A full list of proteins showing nominal significance (p < 0.05) is in Online Table II

^†Proteins showing significant associations with both MPV and PLT

^‡Unit: per standard deviation increment in rank-based inverse normal transformed protein level

^§Bonferroni-corrected significance threshold for 71 proteins P = 0.05/71 = 7.04E-04