Table 3. Steady-state enzyme-kinetic parameters of OXA-436 compared with OXA-48.
The data are reproduced from Samuelsen et al. (2018 ▸). The values for OXA-48 were initially reported by Docquier et al. (2009 ▸).
| Km (µM) | kcat (s−1) | kcat/Km (µM s−1) | ||||
|---|---|---|---|---|---|---|
| Substrate | OXA-436 | OXA-48 | OXA-436 | OXA-48 | OXA-436 | OXA-48 |
| Ampicillin | 5 | 395 | 600 | 955 | 120 | 2.4 |
| Imipenem | 20 | 13 | 6 | 4.8 | 0.30 | 0.37 |
| Meropenem | 3 | 11 | 0.14 | 0.07 | 0.05 | 0.01 |