TABLE 5.
Percentage of patients assigned to each dose level using the marginal, joint, and joint/marginal methods with N=18.
| Dose Level | |||||
|---|---|---|---|---|---|
| 1 | 2 | 3 | 4 | 5 | |
| Scenario 5 | |||||
| Probability of DLT by Clinician | 0.05 | 0.10 | 0.16 | 0.25 | 0.40 |
| Probability of DLT by Patient | 0.05 | 0.20 | 0.35 | 0.50 | 0.65 |
| Probability of DLT by Clinician/Patient | 0.10 | 0.30 | 0.50 | 0.65 | 0.80 |
| % assigned by CRM | 11 | 16 | 24 | 27 | 22 |
| % assigned by PRO-CRM-marginal | 16 | 34 | 36 | 12 | 2 |
| % assigned by PRO-CRM-joint | 13 | 27 | 37 | 19 | 4 |
| % assigned by PRO-CRM-joint/marginal | 13 | 26 | 37 | 19 | 5 |
| Scenario 6 | |||||
| Probability of DLT by Clinician | 0.05 | 0.18 | 0.20 | 0.25 | 0.40 |
| Probability of DLT by Patient | 0.17 | 0.35 | 0.50 | 0.65 | 0.80 |
| Probability of DLT by Clinician/Patient | 0.20 | 0.50 | 0.65 | 0.80 | 0.90 |
| % assigned by CRM | 15 | 23 | 21 | 22 | 19 |
| % assigned by PRO-CRM-marginal | 36 | 45 | 16 | 3 | 0 |
| % assigned by PRO-CRM-joint | 25 | 45 | 23 | 6 | 1 |
| % assigned by PRO-CRM-joint/marginal | 26 | 43 | 24 | 6 | 1 |
| Scenario 7 | |||||
| Probability of DLT by Clinician | 0.01 | 0.05 | 0.10 | 0.16 | 0.25 |
| Probability of DLT by Patient | 0.04 | 0.05 | 0.20 | 0.35 | 0.50 |
| Probability of DLT by Clinician/Patient | 0.05 | 0.10 | 0.30 | 0.50 | 0.65 |
| % assigned by CRM | 7 | 10 | 16 | 23 | 44 |
| % assigned by PRO-CRM-marginal | 8 | 14 | 32 | 34 | 12 |
| % assigned by PRO-CRM-joint | 8 | 11 | 25 | 35 | 21 |
| % assigned by PRO-CRM-joint/marginal | 8 | 11 | 25 | 35 | 21 |