TABLE 7.
Percentage of recommendations of each dose level using the marginal, joint, and joint/marginal methods with N=40.
| Dose Level | |||||
|---|---|---|---|---|---|
| 1 | 2 | 3 | 4 | 5 | |
| Scenario 5 | |||||
| Probability of DLT by Clinician | 0.05 | 0.10 | 0.16 | 0.25 | 0.40 |
| Probability of DLT by Patient | 0.05 | 0.20 | 0.35 | 0.50 | 0.65 |
| Probability of DLT by Clinician/Patient | 0.10 | 0.30 | 0.50 | 0.65 | 0.80 |
| % recommended by CRM | 0 | 2 | 27 | 56 | 15 |
| % recommended by PRO-CRM-marginal | 0 | 15 | 73 | 12 | 0 |
| % recommended by PRO-CRM-joint | 0 | 10 | 68 | 22 | 0 |
| % recommended by PRO-CRM-joint/marginal | 0 | 9 | 72 | 19 | 0 |
| Scenario 6 | |||||
| Probability of DLT by Clinician | 0.05 | 0.18 | 0.20 | 0.25 | 0.40 |
| Probability of DLT by Patient | 0.17 | 0.35 | 0.50 | 0.65 | 0.80 |
| Probability of DLT by Clinician/Patient | 0.20 | 0.50 | 0.65 | 0.80 | 0.90 |
| % recommended by CRM | 1 | 13 | 28 | 45 | 13 |
| % recommended by PRO-CRM-marginal | 10 | 76 | 14 | 0 | 0 |
| % recommended by PRO-CRM-joint | 6 | 71 | 23 | 0 | 0 |
| % recommended by PRO-CRM-joint/marginal | 4 | 74 | 21 | 0 | 0 |
| Scenario 7 | |||||
| ProbabilityofDLT by Clinician | 0.01 | 0.05 | 0.10 | 0.16 | 0.25 |
| Probability of DLT by Patient | 0.04 | 0.05 | 0.20 | 0.35 | 0.50 |
| Probability of DLT by Clinician/Patient | 0.05 | 0.10 | 0.30 | 0.50 | 0.65 |
| % recommended by CRM | 0 | 0 | 2 | 25 | 73 |
| % recommended by PRO-CRM-marginal | 0 | 0 | 15 | 73 | 12 |
| % recommended by PRO-CRM-joint | 0 | 0 | 10 | 67 | 23 |
| % recommended by PRO-CRM-joint/marginal | 0 | 0 | 9 | 72 | 19 |