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. Author manuscript; available in PMC: 2021 Sep 2.
Published in final edited form as: Ann Neurol. 2021 Mar 6;89(5):1023–1035. doi: 10.1002/ana.26053

FIGURE 2:

FIGURE 2:

Apnea is the determining cause of seizure-induced death. (A) In the event of seizure-induced death, terminal apnea preceded terminal asystole in all mouse models. (B, C) Mechanical ventilation significantly increased survival of audiogenic seizures for W/+EIIA-Cre mice (**p = 0.0205, 2-sided chi-squared = 5.367). (D) For each mouse, ventilation was initiated within 6 seconds of the beginning of the tonic phase and was continued for 21 to 80 seconds. Con = control; PTZ = pentylenetetrazole; WT = wild type.