FIGURE 6:

Tonic diaphragm activity is coincident with tonic phase apnea. (A) Plethysmogram (Pleth), raw diaphragm electromyogram (diaEMG), and root mean square amplitude of diaEMG (RMS) recorded from a D/+ mouse. (B) Electroencephalogram (EEG), Pleth, diaEMG, and RMS recorded during an audiogenic seizure from the same D/+ mouse as in A. Some of the diaEMG signal is clipped (indicated by black horizontal lines) to better depict lower amplitude, preictal signal. (C) Left, expanded 1-s traces from preictal and tonic phase time points indicated in B. Note inspiratory motor oscillation occurs during the preictal period and tonic contraction during the tonic phase. In middle and right panels, the same observation was made during seizures in 2 additional D/+ mice. Insp = inspiration.