Recommendations

1.	Evaluation for CCA in PSC patients with sudden clinical or liver biochemical-related parameters deterioration should always be considered. (Grade I/B)
2.	Screening for CCA via regular cross-sectional imaging with ultrasound or MRI and serial CA19-9 every 6–12 months is recommended. (Grade I/C)
3.	Surgical resection is suggested for CCA patients with the absence of cirrhosis. (Grade II-2/B)
4.	Liver transplantation following neoadjuvant therapy in experienced transplant centers is recommended for patients with early-stage CCA not amenable to surgical resection.(Grade I/B)
5.	Cholecystectomy should be offered to eligible patients with PSC and gallbladder mass lesions to prevent secondary gallbladder adenocarcinoma. (Grade I/C)