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Metabolic regulation of fatty acid synthesis and oxidation. Acetyl-CoA carboxylase (ACC) is positively and negatively regulated by citrate and palmitoyl-CoA, respectively. An important mechanism to prevent simultaneous fatty acid oxidation and synthesis is an increase in cytosolic malonyl-CoA, which allosterically inhibits CPTI activity to prevent mitochondrial import of fatty acyl-CoA molecules for β-oxidation.
