Table 2.

Aggregate replication and validation of suggestive (P < 1 × 10⁻⁵) index variant-trait pairs

Dataset	Sample size	# variants testeda	% directionally consistent	P b
West African	4763	958	52%	0.16
East Asian	1936	486	48%	0.25
South Asian	5849	738	51%	0.96
Follow-up	10 644	959	66%	8.310−26
Fasting glucose	10 879	959	57%	3.910−6

^aVariant numbers vary across ancestries due to the MAF > 0.005 criterion.

^bChi-square test P-value for shared interaction effect signs with primary analysis.