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. Author manuscript; available in PMC: 2021 Sep 2.
Published in final edited form as: Curr Chem Biol. 2007 Sep;1(3):311–316. doi: 10.2174/187231307781662198

Fig. (2). Mechanisms of fibrate action.

Fig. (2).

Fibrates are purported to act through five major mechanisms that are dependent on the PPAR receptor. The polyol pathway that goes through AR in the catalysis of sorbitol formation in the presence of NADPH is an additional pathway in the modulation of triglyceride and lipoproteins levels.