TABLE 1.
Overlapping features between DM and genetic interferonopathies
| AGS | Familial lupus | SAVI | CANDLE | Singleton‐merten | |
|---|---|---|---|---|---|
| Gene/pathway | TREX1, RNASEH2, SAMHD1, ADAR, IFIH1 | TREX1, SAMHD1 | TMEM173 | PSMB8 | IFIH1 DDX58 |
| Cutaneous manifestations | |||||
| Chilblain‐like lesions | + | + | + | + | + |
| Digital necrosis | + | + | + | + | − |
| Panniculitis | Occasional | − | − | − | + |
| Heliotrope rash | − | − | − | + | − |
| Telangiectasia | + | ||||
| Interstitial lung disease | − | − | + | − | − |
| Myositis | − | − | + | + | − |
| Arthritis | − | − | + | + | − |
| Constitutional fever | + | − | + | − | + |
Abbreviations: AGS, Aicardi Goutières syndrome, SAVI, sting‐associated vasculopathy with onset in infancy, CANDLE, Chronic Atypical Neutrophilic Dermatosis with Lipodystrophy and Elevated temperature.